14. Its important to know, however, that some horses can have BOTH types, and will need to managed year-round!What are your treatment and management options? Im not dealing with food allergies but both the company and the vet did not recommend allergy shots for my mare. Vet Dermatol 2015;26(1):23-30, e7-8. 16. Oclacitinib should not be given in dogs younger than 12 months of age due to an increased risk for activating demodicosis, bacterial pneumonia, and other serious infections. After that it would be about $250 every 6 weeks or so if I cant further reduce time between pills. This treatment option is FDA approved for equine asthma, and is very safe with no known side effects. Each dosage is sold per tablet, in 20 count, or 100 count bottles. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . Hydroxyzine is usually given orally twice to three times daily in dogs, cats, horses and birds. A native of Japan, Dr. Hensel subsequently moved to Basel, Switzerland, where she opened a veterinary dermatology practice in 2014. Allergies can develop at any time, in any horse, and for virtually any reason. 1. APQ-01043R3, halved to ensure that the ingredients are equally distributed. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. You may give this medicine with or without food. Renal Anemia, or . I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. 16. Ultimately, my vet did not recommend we go down that route. Apoquel should be administered orally, twice daily for up to 14 days, and then once daily for maintenance therapy. Summer-pasture-associated horses tend to be triggered by spring/summer allergens like grasses and trees, and classic horses tend to be triggered by barn dust and mold spores. Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. There is a new drug available to help allergic horses: Apoquel. 12. Equine Regenerative Therapies for Managing Arthritis in Horses, Infographic | 12 Smart At-Home Biosecurity Practices for Horse Owners, Infographic | How To Keep Your Horses Joints Healthy. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. Dosage Chart Bursatti, Leeches) in Dogs, Cats and Horses. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. holy crapola batman- just had to put my dog back on it (Hes usually on it April through Nov but with the weird weather we got away with waiting until July thankfully) and saw the price increase- yikes! She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. For maintenance therapy, the same dose (0.4 to 0.6 mg oclacitinib/kg bodyweight) should then be administered only once a day. We have had variable results with this treatmet. Vet Dermatol 2016;27(Suppl 1):84 (abstract). While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. These animals require the opposite regimen. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered 14. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol 2019;30(2):110-e30. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is flaxseed. Ortalda C, Noli C, Colombo S, et al. Apoquel tablets are scored to be halved to ensure that the ingredients are equally distributed. How Organized Are Your Horses Health Records? Speak to yourveterinarian in an emergency. 24. Option 3 is using a nebulizer with dexamethasone and/or other drugs. Vet Dermatol Rarely, dogs on Apoquel develop new skin masses; however, a long-term study found no association between Apoquel and the development of malignant cancer. 10. Gonzales AJ, Bowman JW, Fici GJ, et al. Pruritus is a common clinical sign in allergic skin diseases. The second option is serum (blood) testing. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. In the first pilot study, oclacitinib (0.4 to 0.6 mg/kg, q12h for 14 days, then q24h for 14 days) was used to treat pruritus in cats with non-flea, nonfood-induced hypersensitivity dermatitis. I have noticed that in general she is more comfortable on cooler days. 25. Oclacitinib was well tolerated in both studies. I hear the result have been spectacular. Clenbuterol should only be used short-term, since it will stop working with long-term administration. Cost is <$50/month, its easy, and its usually very effective. Apoquel Dosage for Dogs. has been administered by veterinarians to help horses of . Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. This content is intended for counseling purposes only. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days. There are two types of this condition, summer-pasture-associated and classic recurrent airway obstruction (RAO). 2. Cost for the initial course of treatment (about 12 days) will be around $300-400. Her asthma had gotten so bad I thought I wouldnt be able to ride her again, but now we are back to w-t-c. She is down to every other day. Her allergies have reared their ugly heads again - no jowl pyoderma, but ears itching. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. Most recently, it was suggested that the treatment strategy for canine atopic dermatitis might need to be adjusted. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as, While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. Several reports of successful use of oclacitinib to treat other diseases have been published. All dogs itch sometimes, but when you notice it happening more and more, it could be a sign of a medical condition. Dawn M. Cleaver, DVM Associate Director, Regulatory Affairs A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. We recommend Platinum Skin and Allergy or Aleira. In fact, in our. Download Apoquel Information Sheet. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. More severe ones, however, can truly take a toll on your horses health and make him miserable. Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. Panteri A, Strehlau G, Helbig R, et al. 30. Learn how allergies happen, how they affect your horses body, and how to avoid or treat them. Please select your state below. 12. May be used with other common medications. Use code GOODRX20 Sponsored by The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. 7. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Lucile Vigouroux holds a masters degree in Equine Performance, Health, and Welfare from Nottingham Trent University (UK) and an equine veterinary assistant certification from AAEVT. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside, Many allergens can cause skin reactions. Maintaining Your Horses Weight During the Winter, Special Report: Preventing 3 Common Equine Joint Issues, JACKSON- Gelding/Bay/Mustang (Nevada) - Project/Ready for Training, JENNINGS Gelding/Cremello/Mustang (BLM) Ridable (Green), recent study evaluating almost 400 potential allergens, BONNIE: Sorrel Mustang Mare Non-Riding Companion Only. Topics. Apoquel. 1. Unlike steroids, the drug has minimal impact on the immune system. I draw up a little calendar for them each month to help keep track. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Maximizing ventilation when horses are stalled and bedding with low-dust options such as wood byproducts; Purchasing dust- or mold-free hay and wetting, soaking, or steaming it prior to feeding to reduce inhaled particles; and Offering an alternative feed than hay for low-dust options. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Horse dosing is 5 pills. Long term itch reduction. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. 23. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. 19. This medication may be a very good option for minis, since the costs will be much lower. Do not use in breeding, pregnant, or lactating dogs. How Should It Be Given? Trials showed that spreading out dosing was more successful than lowering. These might include antihistamines such as cetirizine, which you can buy over the counter as Zyrtec from any drug store or pharmacy, or hydroxyzine, which requires a veterinary prescription. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. Zyrtec: The human antihistamine may be beneficial in a small proportion of horses with Equine Asthma. Acepromazine affects animals and humans by depressing the central nervous system. Vomiting, diarrhea, and lack of appetite are also possible. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. Equine Nutrition FAQ Series, sponsored by Purina Animal Nutrition. Oral . Vet Dermatol 2015;26(3):171-179, e35. 4. Lopes NL, Campos DR, Machado MA, et al. Apoquel has been a game changer, however. The anti-inflammatory effects of dexamethasone are about twenty-five times stronger than those of natural cortisol. Dr. Nao Hensel obtained her doctor of veterinary medicine degree from Colorado State University in 2010. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Pros and cons of oclacitinib therapy. On the label for dogs, Apoquel is used every 12 hours for the first 14 days of use, then backed down to dosing every 24 hours once a day. APOQUEL may be administered with or without food. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production.1 In recent studies, IL-31 has been shown to play an important role in pruritus, and elevated serum levels of IL-31 have been found in many atopic dogs.2, There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31).4. Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. There are a few medication protocols for horses with Equine Asthma. 15. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. In some dogs, this can be overcome by splitting the total daily dose in half and give twice daily. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. 8. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. Ordering patient medications is easy. Apoquel should not be used in breeding, pregnant, or lactating dogs. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. An antibody called immunoglobulin E (IgE) is produced when the body detects an allergen, says Samuel White, PhD, a professor of equine science at Nottingham Trent University, in England, known for his research on allergen identification and diagnostic development in the horse. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. Have you considered trying allergy testing? The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. This site is intended for US animal healthcare professionals. Vet Dermatol 2014;25:153 (abstract). 18. Several of their drugs are eligible. Webcast | The Janus kinases (Jaks). 13. Remove all nonessential supplements and topical solutions from your horses diet and routine. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. So I want to make sure she has the support she needs to acclimate to hot humid summer weather. These inhaled substances can trigger an allergic response that causes narrowing of the airways, mucous secretion, and cough., Luckily, minimizing common allergens in your horses environment could suffice to restore his comfort and breathing. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. Yamaoka K, Saharinen P, Pesu M, et al. You are encouraged to speak with your prescriber as to the appropriate use of any medication. KER offers EO3, which contains the omega-3 fatty acids DHA and EPA. Some allergic reactions are unexpected, as White has realized through his research. She added, "Studies show that omega-3 fatty acids help horses with equine asthma. I havent noticed any abnormal side effects. And some can got a lower dose or a further spread out dose. This site is for US animal healthcare professionals. The recommended Apoquel (main ingredient, oclacitinib) dosage for dog use is as follows: The recommended dosage is 0.18 to 0.27 mg of oclacitinib per pound of body weight, for the first 14 days. The most common practical starting dosage for many cats is of the 5.4mg tablet, or 2.7mg. Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. The efficacy and safety of oclacitinib have been assessed in various studies. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Unfortunately since her allergies have jumped from skin to also being respiratory, zyrtec even 15 pills 2x a day does not do anything and even dex only worked at high doses. Allergies can develop at any time, in any horse, and seemingly for any reason. Having allergy tested 3 horses you can get a serum for some allergens but not all. Avoid giving the medicine twice daily long-term. 7. We do a loading dose for 7 days, then every other day for 7 doses (so 14 days) then work to figure out how far apart we can go with our daily dose. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. Collard WT, Hummel BD, Fielder AF, et al. 29. The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. to 14 days, and then administered once daily for maintenance therapy. Nobody wants to be itchy and constantly scratching. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control.16, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20 shutterstock.com/Thrithot, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. Dexamethasone commonly is used in horses to treat allergic reactions such as respiratory allergies, chronic obstructive pulmonary disease (heaves), hives, itching and inflammatory diseases including arthritis. But I had my mare tested last year, she also came up allergic to some foods (flax being one) for which I was told serum was not an option. Do not use in breeding, pregnant, or lactating dogs. Fortunately, these side effects are relatively uncommon. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs. Apoquel starts relieving allergic dog itch and inflammation due to skin allergies within 4 hours and controls it within 24 hours. EHV Quarantine Released at Turf Paradise Racetrack, Six Simple Spring Safeguards for Senior Horses, Evaluating the Suspensory Ligament in Cutting Horses, Regular Dental Care Important in Horses Worldwide, Investigating Equine Cases of Toxicant Exposure, Podotrochlosis: Navicular is No Longer the End of the Road for Horses. Rectal Prolapse in Dogs and Cats. Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? Drake GJ, Nuttall T, Lpez J, et al. 2022 Zoetis Services LLC. If you must give corticosteroids to an asthmatic horse, your veterinarian might prescribe them to be administered via an aerosol route through the nostril (rather than orally or via injection), which minimizes the amount that gets into the general circulation. Like other medications in its class, it may also be used off . See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. It generally reduces itching very quickly within 24 hours and is felt to be as effective as corticosteroids. In severely affected horses, we would expect to see lower airway inflammation and airway obstruction, manifesting as increased respiratory effort, frequent coughing, mucous buildup, and exercise intolerance, White says. Loft K, Simon B. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. To overcome its delayed effect, cyclosporine is often initially combined with other drugs such as prednisolone to accelerate the anti-inflammatory and antipruritic effects. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. $ 78.30 - $ 245.00. Im glad that youve found a solution- but, after the allergy testing you can start them on a regimen designed exactly for what they are allergic to, which will help to desensitize them to those allergens. The innovative formula of the drug allows you . So new drugs such Atopica and Apoquel are prescribed routinely, to help dog owners find a quick fix for dog allergies. In the first pilot study, oclacitinib (0.4 to 0.6 mg/kg, q12h for 14 days, then q24h for 14 days) was used to treat pruritus in cats with non-flea, nonfood-induced hypersensitivity dermatitis. Well, one of mine is allergic to soy, corn, oats, flax and more and they were able to create just the right stuff for him. Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. Submit Office Orders & Patient Prescriptions. Let's look at the differences between these two medications, as well as some other treatment options for your dog's allergies. For example: 1,000 lb horse X 10 mg/lb = 10,000 mg. These molecules are responsible for the appearance of clinical signs commonly associated with allergies, such as itching., Horses environments are full of substances that can trigger the immune system and cause allergies. Ortalda C, Noli C, Colombo S, et al. Gadeyne C, Little P, King VL, et al. Simple strategies for dust reduction include removing the horses from the stalls when mucking out and blowing the aisle or ditching the leaf blower altogether, Fultz says. IgE binds to cells in the body and releases inflammatory molecules. During this period, the drug is administered twice daily, with an interval of 12 hours. . Dosing Chart Contraindications A Magnawave-certified practitioner, Lucile also runs a small equine PEMF therapy business. J Vet Pharmacol Ther 2014;37(3):279-285. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. The bodys largest organ, the skin serves as the immune systems first protective barrier. Most horses in our area of North Carolina are "Summer-Pasture-Associated" asthma patients, so we recommend starting yearly treatment or management in March or April. Eur J Pharmacol 2017;794:20-26. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. Apoquel Dosage in Dogs Apoquel tablets for dogs comes strengths of 3.6mg, 5.4 mg and 16mg of oclacitinib per tablet. Powered by Discourse, best viewed with JavaScript enabled. RELATED CONTENT | Infographic: Equine Allergies. J Biol Chem 2007;282(28):20059-20063. Thereafter the dose should be reduced to once daily for maintenance. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. The efficacy and safety of oclacitinib have been assessed in various studies. The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. 2: The Barn and Pasture: Horses with Summer-Pasture-Associated disease usually have less symptoms when kept in the barn during the warmer months. That something could very well be allergy-induced asthma. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). Genome Biol 2004;5(12):253. Apoquel doses are usually between .04-.06 milligrams per kilogram of body weight (mg/kg) . 20. However, the twice-daily use must not last for more than 14 days. 2. These are known as allergy shots. "Even though the drug is currently labeled for use in dogs (with. Pros and cons of oclacitinib therapy. Thereafter the dose should be reduced to once daily for maintenance. Avoiding Allergies Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. Option 1 is the cheap/easy route, but comes with risks. Generally self-limiting and harmless, hives are nonetheless uncomfortable and can occasionally lead to angioedema (swelling under the skin) or purpura (blood vessels rupturing and leaking blood internally). 3. Insect and pollen season is here. Apoquel is an anti-itch tablet given twice daily for the first . BMC Vet Res 2019;15(1):137. No claims are made as to the safety or efficacy of mentioned preparations. Comparing Apoquel and Cytopoint. The Janus kinases (Jaks). Pulsoni D, Freire A, Ferreira DR. Juvenile-onset ischemic dermatopathy in two dogs treated with oclacitinib. Collard WT, Hummel BD, Fielder AF, et al. Initially, the recommended dose of 0.4 to 0.6 mg/kg should be given twice daily for up to 14 days. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Pre-slaughter withdrawal time is 14 days following the last dose. Unlike steroids, the drug has minimal impact on the immune system. Your veterinarian also may use dexamethasone in high doses in emergencies for anaphylactic reactions, spinal cord trauma or shock. Give one chewable per month to the dog. Option 2 is the Aservo Equihaler.